Blessed with a dramatic setting on the steep banks of the river Douro, Portugal’s second city is currently enjoying something of a renaissance, and is best known as the home of the country’s most famous export, port wine.

Vigo is the biggest city in Galicia, Spain’s verdant northwest corner. The city itself is a busy fishing port with limited tourist appeal, but it’s a great base for striking out into the countryside, visiting the lovely Cíes Islands just offshore or joining the pilgrims in Santiago de Compostela, 60 miles to the north.

Bordeaux sits at the centre of the world's most famous wine region, and is home to a beguiling blend of beautiful buildings, sophisticated gastronomy and high culture. It's a marvellous place to spend some time, whether it's a day sampling wines, an evening at the opera or a night on the tiles.

Santander is the largest city on the Cantabrian coast, although perhaps not the prettiest, having lost many of its oldest buildings in a fire in 1941. Nevertheless, pockets of belle époque elegance remain, and the old town has some lively bars and restaurants. The beautiful medieval village of Santillana del Mar is a popular day trip from here.

It’s not so long ago that Bilbao was a grim and unappealing place, scarred by heavy industry, but the Basque Country’s biggest city has reinvented itself as a cultural hub since the opening of the shimmering Guggenheim Museum in 1997.

Gijón is the largest city in the Asturias region of northern Spain, an important industrial port but also a lively and youthful place, ideally positioned for exploring the Costa Verde. The most interesting area is the historic fishing village of Cimadevilla, which sits on a peninsula that divides the bay in two.