Basel lies where Switzerland, France and Germany meet, a sophisticated and multicultural city with a picturesque setting astride the river Rhine. The medieval Old Town is exceptionally well preserved, best appreciated from the summit of the hilltop cathedral, which offers incredible views across the city.

Strasbourg is the capital of France’s Alsace region, right next to the border with Germany, and there is a tangible Germanic influence that sets the city a little apart from the rest of France. Highlights include the beautiful Gothic cathedral, the old town’s fairytale half-timbered houses, and the pictureque canals of the Petite France district.

The famous spa town of Baden-Baden has been attracting the great and the good for some 2,000 years, with everyone from Otto von Bismarck to Barack Obama taking the waters here. Even if thermal baths aren’t your thing, you’re sure to be enchanted by the beautiful architecture and the storybook setting next to the Black Forest.

Situated near the confluence of the Rhine and Neckar rivers, Mannheim is an important industrial centre with a lively cultural scene. It’s also conveniently located for exploring the pretty town of Heidelberg and the wine growing region around Nierstein.

Koblenz was founded by the Romans, who valued the city’s strategically important location where the Rhine and Moselle rivers meet. Rebuilt from the rubble of the Second World War, modern Koblenz has a pleasant and relaxed atmosphere, and serves as a gateway to the Romantic Rhine.

Cologne is a wonderfully warm and welcoming city, its skyline dominated by one of the most beautiful Gothic cathedrals in Europe. You will likely spend most of your time in the attractive Altstadt (Old Town), home to beer halls aplenty and some fascinating museums.