Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.

Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe, and the city remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

Çanakkale occupies a key strategic location guarding the Dardanelles, at the meeting point of the Aegean and the Sea of Marmara. This region of Turkey is full of historical interest, including the battlefields of the disastrous Gallipoli campaign and the ruins of ancient Troy.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

Crete’s bustling capital is a modern and cosmopolitan city, where the island’s rich history isn’t immediately apparent. Take a closer look, however, and you’ll find a fantastic archaeological museum, along with remnants of Venetian fortifications and a lively seafront promenade, with plenty of nice outdoor cafés.

Tunisia’s capital is a whirlwind of energy, the narrow lanes of the old medina packed with people and the roads noisy with traffic. The more orderly streets of the Ville Nouvelle are home to some handsome colonial buildings, while the ruins of ancient Carthage make for a fascinating day trip.

Palermo is an acquired taste; noisy, chaotic and rather grimey in places. But there’s something quite intoxicating about the crumbling facades and the bustling markets, and the Arabesque style of many of the buildings hints at Sicily’s historical role as a stepping stone between Europe and North Africa.

The picturesque little town of Amalfi was once a major Mediterranean naval power, but a devastating earthquake in 1343 cut the city down in its prime and destroyed most of its historic buildings. These days, of course, Amalfi is best known for the eponymous stretch of stunning coastline on which it sits.

One of the world’s great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

Salerno is the capital of the Campania region, an attractive city at the eastern end of the Amalfi Coast. The historic centre and beautiful seafront promenade are well worth exploring, and the ruins at nearby Paestum make for an interesting day trip.

Taormina enjoys a truly spectacular setting on Sicily’s east coast, perched on a mountainside looking out towards the smouldering Mount Etna. The medieval streets are pleasant but often crowded in high season, so we’d recommend getting out and exploring the surrounding countryside.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

Although Ibiza is best known as a hedonistic party island, it’s easy to give the clubbers a swerve and discover the White Isle’s mellower side. The island boasts some spectacularly beautiful coastline, and the fortified Old Town (Dalt Vila) is UNESCO listed.

Spain’s third city is a dazzling destination that combines historic architecture, cutting edge design and an inviting stretch of beach. Don’t miss the futuristic City of Arts and Sciences, designed by local architect Santiago Calatrava, or the old riverbed, now a delightful park.

From the warren-like medieval streets of the Barri Gòtic to the fantastical modernist architecture of Antoni Gaudí, from the dizzy heights of Mount Tibidabo to the golden sands of Barceloneta, there’s never a dull moment in Barcelona.

The rumbustious port of Marseille often gets a bad press, but the city has been transformed in recent years, with a host of new cultural attractions. The vibrant Vieux Port remains at the heart of life in Marseille, however, and is the best place to begin your exploration of the city’s many historic sights.

Few ports conjure up images of glitz and movie star glamour quite so readily as Cannes. May is when the glitterati roll into town for the Film Festival, but there’s still plenty to divert you the rest of the year, including the old quarter, Le Suquet, and the dazzling Croisette.