The down-to-earth port of Sète, sandwiched between the Mediterranean and the Etang de Thau lagoon, is a working town rather than a tourist hotspot, though the canals and colourful buildings have a certain charm. It’s also a great spot for a seafood lunch, and a visit to the nearby citadel of Carcassonne is a popular excursion.

The rumbustious port of Marseille often gets a bad press, but the city has been transformed in recent years, with a host of new cultural attractions. The vibrant Vieux Port remains at the heart of life in Marseille, however, and is the best place to begin your exploration of the city’s many historic sights.

Nice enjoys a marvellous setting on one of the most glorious stretches of the Côte d’Azur, the sweeping Bay of Angels, so it’s no wonder that tourists have been flocking here since the 19th century.

The faded port town of Livorno serves as a gateway to Tuscany’s star attractions. Wonderful Florence, the cradle of the Renaissance, is resplendent with beautiful architecture and unrivalled artistic treasures, while nearby Pisa is of course famous for its precarious Leaning Tower.

One of the world’s great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

The UNESCO World Heritage-listed centre of Naples rewards exploration, and in addition to the many cultural treasures waiting to be unearthed Neapolitans are rightly proud of their food; this is where you’ll find the best pizza in Italy. The city also acts as a gateway to the fascinating remains of Pompeii and Herculaneum, and the beautiful Amalfi coast.

Situated on the north eastern tip of Sicily, so close to the Italian mainland you can almost touch it, Messina is the busy main entry point to the island. The city was flattened by an earthquake in 1908, and again by Allied bombing in 1943, so few historical sights remain, although the cathedral is one of Sicily’s most impressive.

The Calabrian city of Crotone was once an important Greek colony, home to the mathematician Pythagoras, and some ruins still survive at Capo Colonna, to the south of the modern city. Another popular excursion is a visit to the fishing village of Le Castella, where a fairytale castle sits on an island at the end of a narrow causeway.

Bari is the second biggest city in southern Italy, situated at the heart of sunny Puglia. The delightful old town brims over with pretty churches and balconied houses, and the striking Basilica is said to house the bones of Saint Nicholas. Easy day-trips include the trulli houses of Alberobello and the stunning hilltop city of Matera.

One of the Dalmatian coast’s lesser known cities, Šibenik is notable for its compact medieval centre, UNESCO-listed Gothic-Renaissance cathedral and crumbling fortresses. The nearby islands of Zlarin and Prvić also make for an enjoyable day trip.