The former papal stronghold of Avignon cuts a dramatic figure, perched above the Rhône and ensconced behind towering walls. The Palais des Papes was home to a succession of 14th century pontiffs, and still looms large over Avignon’s atmospheric old town.

The little town of Viviers, on the right bank of the Rhône, is a delightful place to explore on foot, with its narrow, cobbled medieval streets and elegant cathedral. A lot of history is packed into a small space, including Roman remains and the Renaissance era Maison des Chevaliers.

Vienne was an important trading centre during Roman times, and spectacular remnants of this era survive, including a remarkably well preserved temple and a hillside amphitheatre with marvellous views across the red-tiled rooftops. The city also hosts a renowned jazz festival during July, featuring some of the world’s most talented musicians.

Situated at the confluence of the Rhône and Saône rivers, Lyon is one of France’s most appealing cities. Its reputation for gastronomic excellence is well deserved, with hundred of wonderful restaurants, and the UNESCO listed historic centre boasts a marvellous ensemble of Renaissance-era buildings.

The little town of Mâcon lies on the west bank of the Saône, at the southern edge of Burgundy, and it’s a great base for sampling the region’s famous wines. A popular excursion is a trip to nearby Beaune, home to the magnificent medieval Hospices de Beaune and its prestigious wine estate.

The riverside town of Tournus is known for the magnificent Benedictine Abbey of Saint Philibert, of which the Romanesque 11th-century church is the main surviving element. Other nearby sights include the splendid Château de Cormatin, the medieval village of Brancion and the Mâconnais wine region, home of the Chardonnay grape.

Chalon-sur-Saône was once a key trading centre and port, situated at the meeting of Roman roads, the river Saône and several other inland waterways. The city’s distinguished history is reflected in its handsome buildings, and this is an excellent base from which to explore the southern Burgundy wine regions.