Salerno is the capital of the Campania region, an attractive city at the eastern end of the Amalfi Coast. The historic centre and beautiful seafront promenade are well worth exploring, and the ruins at nearby Paestum make for an interesting day trip.

Palermo is an acquired taste; noisy, chaotic and rather grimey in places. But there’s something quite intoxicating about the crumbling facades and the bustling markets, and the Arabesque style of many of the buildings hints at Sicily’s historical role as a stepping stone between Europe and North Africa.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

The charming port of Agios Nikolaos, on the north east coast of Crete, offers a beguiling blend of characterful tavernas, lively bars and designer boutiques. The town is centred around little Lake Voulismeni, and nearby attractions include some lovely beaches and the Minoan ruins at Gournia.

Marmaris is one of Turkey’s biggest beach resorts, with the crowds to match. It’s easy to see why so many are drawn here, with a great location on a mountainous bay, but we’d recommend heading further along the coast in search of quieter beaches and picturesque fishing villages.

Antalya is the biggest and busiest city on the Turkish Riviera, though there’s more to this place than just roasting on a beach. The historic Kaleiçi district is full of lovingly restored Ottoman mansions, and top attractions include the superb collection of classical treasures at the Antalya Museum, with pieces from the nearby archaeological sites of Perge and Aspendos.

Kos is the second largest of the Dodecanese Islands after Rhodes, and is best known for its excellent beaches. There are plenty of cultural treasures here too: Kos Town’s harbour is guarded by an impressive castle built by the Knights of St John, and the island is scattered with Greek and Roman ruins.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

The Turkish port of Izmir, formerly the Greek city of Smyrna, is a liberal and progressive place where the secularism of Ataturk remains strong. During the Ottoman era this was a melting pot of ethnic groups including Armenians, Jews and Italians, and a cosmopolitan atmosphere persists to this day.

Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe, and the city remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

The North Aegean port of Dikili is the gateway to the spectacular hilltop ruins of Pergamum, a 30-minute drive away. Most of the buildings here date back to the 2nd century BC, including the main palace, the library and the Altar of Zeus, and the ruins were declared a UNESCO World Heritage Site in 2014.

Bodrum is one of the trendiest destinations on Turkey’s Aegean coast, with plenty of private yachts bobbing alongside the traditional gulet boats in the harbour. Whitewashed buildings draped in bougainvillea give the town a Greek feel, overlooked by the imposing 15th century crusader castle.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The buzzing city of Limassol is southern Cyprus’ main port, an important commercial hub that overflows with bars, restaurants and tavernas. It’s also home to a pleasant old town and medieval castle, and serves as an excellent base for exploring the nearby Troodos mountains.

Marmaris is one of Turkey’s biggest beach resorts, with the crowds to match. It’s easy to see why so many are drawn here, with a great location on a mountainous bay, but we’d recommend heading further along the coast in search of quieter beaches and picturesque fishing villages.

Crete’s bustling capital is a modern and cosmopolitan city, where the island’s rich history isn’t immediately apparent. Take a closer look, however, and you’ll find a fantastic archaeological museum, along with remnants of Venetian fortifications and a lively seafront promenade, with plenty of nice outdoor cafés.

Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.