The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

The charming port of Agios Nikolaos, on the north east coast of Crete, offers a beguiling blend of characterful tavernas, lively bars and designer boutiques. The town is centred around little Lake Voulismeni, and nearby attractions include some lovely beaches and the Minoan ruins at Gournia.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

Saint John is said to have written the Book of Revelations in a cave on Patmos, and today the spot is marked by the hillside Monastery of the Apocalypse. As well as spirituality, the island is known for its beaches and upmarket vibe, with a scattering of stylish restaurants and bars.

Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.

Athens is a city awash with historical and cultural significance, but it's much more than an open air museum; this is a dynamic, bustling metropolis, and a place where history is still very much unfolding.

The little seaside town of Katakolon, on the western coast of the Peloponnese, is the gateway to ancient Olympia, birthplace of the Games and the place where the Olympic flame begins its journey every four years. Make the most of your visit with a guided tour of the ruins, and don’t miss the treasures of the Archaeological Museum.

Sarandë is southern Albania’s premier seaside resort, and in summer the population swells with day-trippers from nearby Corfu. If the beach doesn’t appeal then visit the fascinating archaeological remains at Butrint, or take a dip in the refreshing waters of the beautiful Blue Eye Spring.

Founded by Greek colonists in 734 BC, Siracusa was once the largest city in the ancient world, surpassing even Athens in its splendour. Highlights include the island of Ortigia, where narrow streets are lined by beautiful Baroque architecture, and the impressive ruins at the Parco Archeologico della Neapolis on the Sicilian mainland.

Busy, noisy and a little bit scruffy, Catania is Sicily’s second city, poised perilously in the shadow of Mount Etna. In recent years gentrification has taken hold, and the city’s many beautiful palazzi and baroque churches have been restored to their former glory. Eating out here is also a real treat.

Salerno is the capital of the Campania region, an attractive city at the eastern end of the Amalfi Coast. The historic centre and beautiful seafront promenade are well worth exploring, and the ruins at nearby Paestum make for an interesting day trip.

One of the world’s great cities, Rome continues to dazzle and delight visitors with a potent mix of architectural marvels, continent-defining history and buzzing nightlife. The Colosseum, the Vatican and the Forum are among the big ticket items, with the crowds to match, though in truth you will find history around almost every corner.

The faded port town of Livorno serves as a gateway to Tuscany’s star attractions. Wonderful Florence, the cradle of the Renaissance, is resplendent with beautiful architecture and unrivalled artistic treasures, while nearby Pisa is of course famous for its precarious Leaning Tower.

Genoa has a legendary seafaring heritage, and was once a powerful maritime republic. However, the city’s most famous son, Christopher Columbus, was spurned by the Genoese elite when he came looking for funds for his expedition, and his discoveries for the Spanish Crown ironically played no small part in Genoa’s downfall.

Nice enjoys a marvellous setting on one of the most glorious stretches of the Côte d’Azur, the sweeping Bay of Angels, so it’s no wonder that tourists have been flocking here since the 19th century.

The rumbustious port of Marseille often gets a bad press, but the city has been transformed in recent years, with a host of new cultural attractions. The vibrant Vieux Port remains at the heart of life in Marseille, however, and is the best place to begin your exploration of the city’s many historic sights.

The bustling fishing village of Palamós is one of the loveliest spots on the Costa Brava, surrounded by beautiful beaches and rugged coves. You can also use your stop here as a jumping off point for exploring nearby medieval villages, the historic city of Girona or the fantastic Salvador Dalí museum in Figueres.

From the warren-like medieval streets of the Barri Gòtic to the fantastical modernist architecture of Antoni Gaudí, from the dizzy heights of Mount Tibidabo to the golden sands of Barceloneta, there’s never a dull moment in Barcelona.

Spain’s third city is a dazzling destination that combines historic architecture, cutting edge design and an inviting stretch of beach. Don’t miss the futuristic City of Arts and Sciences, designed by local architect Santiago Calatrava, or the old riverbed, now a delightful park.

Cartagena was founded by the Carthaginians around 227 BC, who named it after their home city in North Africa. These days the city is best known for its well-preserved Roman theatre, which was remarkably only discovered in 1987, in spite of its location in the centre of town.

Málaga boasts plenty of chic restaurants and bars where you can ease into the rhythms of life in southern Spain, before exploring sights including the intriguing, unfinished Gothic cathedral, and a museum devoted to the city's most famous son, Pablo Picasso.

Sovereignty of ‘The Rock’ has been a thorny issue ever since Gibraltar was ceded to Britain in 1713, though on the ground it’s clear where most locals’ sympathies lie. Gibraltar is often described as ‘more British than Britain’, a curious enclave of red postboxes, double decker buses and chip shops.

Seville is a wonderful destination, a sophisticated and sun-kissed city on the banks of the Guadalquivir river. It’s a treat for all the senses, from the smell of orange blossom to the heart-tugging sounds of flamenco, and the highlight of the calendar is undoubtedly Semana Santa, when a spectacular Easter parade fills the streets.